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M94A0345.TXT
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1994-10-08
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Document 0345
DOCN M94A0345
TI Transitory expansion of a CD3+TcR gamma/delta+CD16+ lymphocytic
population in two patients with advanced human immunodeficiency virus
infection and high levels of natural killer activity.
DT 9412
AU Tambussi G; Albarello V; Gori A; Bisson C; Lazzarin A; Department of
Infectious Diseases, San Raffaele Hospital, Milan,; Italy.
SO AIDS Res Hum Retroviruses. 1994 Jun;10(6):711-5. Unique Identifier :
AIDSLINE MED/94355116
AB In the present study, we describe an expansion of CD16+ cells with a
CD3+ TcR gamma/delta+ phenotype, in the presence of normal numbers of
classic CD3-CD16+ natural killer (NK) cells, in two patients with human
immunodeficiency virus (HIV) infection in late stage. The NK activity of
the two subjects was substantially higher then that of HIV+ subjects in
the same stage of infection. A second evaluation of one of the patients
showed levels of NK activity consistent with the clinical stage of HIV
infection, concomitant with a remarkable reduction in the percentage of
double-positive CD3/TcR gamma/delta cells. The number of CD16+ cells
also reached values comparable to those of the control group. In
conclusion, we have identified a population of CD3+TcR gamma/delta+CD16+
cells that have the capability to lyse an NK-sensitive target in two
patients with unusually high levels of NK activity.
DE Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY Adult Antigens,
CD3/*ANALYSIS Case Report Human Immunophenotyping *Killer Cells,
Natural/PHYSIOLOGY *Lymphocyte Subsets Male Receptors, IgG/*ANALYSIS
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).